Brisket - this is what I do.
Trimming
Rub:
2/3 cup sugar
2/3 cup garlic salt
1/2 cup paprika
3 tbsps pepper
2 tbsps chili powder
1 tbsp of ginger, onion powder, coriander, cayenne pepper, powdered beef bullion
Some people use just salt and pepper, some use mustard to help the rub stay on...