Not with commercial yeast, which is generally K-meta resistant.
I pour K-meta into primaries, going around the top of the container so all surfaces get wet, the pour the K-meta back into the jug and shake out the excess. If this doesn't bother the yeast, a spritzing won't.
At the same time, making a good starter helps ensure the yeast gets off to a good start. For decades I simply sprinkled yeast on top of the must or did a 15 minute hydration, and it often took days for the ferment to start. In the year I've been making overnight starters, I've experienced what feels like remarkable results, but is honestly just applied common sense.