It is crown gall. Is it below a graft or at the graft? If so, cut it off below the gall and paint the open wound with undiluted Roundup to kill all the root. Let the spot lie fallow for two years. Other vines may or may not be affected.
Crown gall is in the soil so not much you can do to avoid it entirely. I have a few vines that succumbed. Mine is mostly due (I think) to sudden sub freezing temperatures. Young vines succumb faster.