Thanks all, for the informed responses and links. I too suspect it might be leafroll from this, that seems to be the closest match.
Regent vines are meant to have superior resistance to mildews and the like (which is why I selected them for the UK, given the temperate climate). As everyone probably knows, this variety was developed from a cross in Germany. I've been searching through German language forums and found one other possibility called "Rotter Brenner" which seems to be an internal fungus that Regent is highly susceptible to. It's early days and I'm trying to translate everything using google, but if this looks more likely than leafroll I'll report back.
I bought the vines 2 years ago from a UK distributor. They were grafted so there's also the chance that the rootstock was infected.